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Filtered Search Results
eMolecules Ambeed / 4-(Methylthio)benzaldehyde / 1g / 490490170 / A104523 / / 3446-89-7 / MFCD00006948 / 152.210 / C8H8OS
Ambeed / 4-(Methylthio)benzaldehyde / 1g / 490490170 / A104523 / / 3446-89-7 / MFCD00006948 / 152.210 / C8H8OS
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Medchemexpress LLC SMYD3-IN-1 | 2095160-79-3 | 98.0% | 100 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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SMYD3-IN-1 is an irreversible and selective inhibitor of SMYD3, with an IC50 of 11.7 nM. It is intended for research use only. This compound has a molecular weight of 507.02, a chemical formula of C28H31ClN4O3, and appears as an off-white to pink solid. It exhibits solubility of 100 mg/mL in DMSO.
- Selective SMYD3 inhibitor with an IC50 of 11.7 nM
- Molecular weight of 507.02
- Chemical formula: C28H31ClN4O3
- Appears as an off-white to pink solid
- Solubility of 100 mg/mL in DMSO
- GI50 of 1.04 μM in HepG2 cells for inhibition of SMYD3 in anchorage-independent colony formation
- GI50 of 17.69 μM in HepG2 cells for inhibition of cell proliferation
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eMolecules ChemScene / 3-Iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carboxylic acid / 100mg / 572167050 / CS-0017742 / 0.000 / 1627924-17-7 / MFCD29918654 / 322.102 / C9H11IN2O3
ChemScene / 3-Iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carboxylic acid / 100mg / 572167050 / CS-0017742 / 0.000 / 1627924-17-7 / MFCD29918654 / 322.102 / C9H11IN2O3
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC SR-4835 | 2387704-62-1 | 99.5% | 50 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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SR-4835 is a potent, highly selective, and ATP-competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). It acts synergistically with DNA-damaging chemotherapy and PARP inhibitors, leading to cell death in triple-negative breast cancer (TNBC) cells.
- Potent, highly selective, and ATP-competitive dual inhibitor of CDK12/CDK13
- Inhibits CDK12 (IC50=99 nM, Kd=98 nM)
- Inhibits CDK13 (Kd=4.9 nM)
- Acts synergistically with DNA-damaging chemotherapy and PARP inhibitors
- Leads to cell death in triple-negative breast cancer (TNBC) cells
- Suppresses ATM and RAD51 protein levels
- Triggers intronic polyadenylation site cleavage
- Suppresses expression of core DNA damage response proteins
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eMolecules Ambeed / 6-Methoxy-2-pyrazinecarboxylic acid / 100mg / 552726626 / A412001 / / 24005-61-6 / MFCD00233277 / 154.125 / C6H6N2O3
Ambeed / 6-Methoxy-2-pyrazinecarboxylic acid / 100mg / 552726626 / A412001 / / 24005-61-6 / MFCD00233277 / 154.125 / C6H6N2O3
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![eMolecules Ambeed / (3aR8aS)-2-(Quinolin-2-yl)-3a8a-dihydro-8H-indeno[12-d]oxazole / 50mg / 589770126 / A1219941 / / 2095128-11-1 / [null] / 286.334 / C19H14N2O](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502436018.JPG-250.jpg)
eMolecules Ambeed / (3aR8aS)-2-(Quinolin-2-yl)-3a8a-dihydro-8H-indeno[12-d]oxazole / 50mg / 589770126 / A1219941 / / 2095128-11-1 / [null] / 286.334 / C19H14N2O
Ambeed / (3aR8aS)-2-(Quinolin-2-yl)-3a8a-dihydro-8H-indeno[12-d]oxazole / 50mg / 589770126 / A1219941 / / 2095128-11-1 / [null] / 286.334 / C19H14N2O
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eMolecules ChemScene / 5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid / 100mg / 572282304 / CS-0061732 / 0.000 / 58364-97-9 / MFCD10699178 / 142.114 / C5H6N2O3
ChemScene / 5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid / 100mg / 572282304 / CS-0061732 / 0.000 / 58364-97-9 / MFCD10699178 / 142.114 / C5H6N2O3
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eMolecules Ambeed / 6-Chloro-4-methylpyridine-2-carboxylic acid / 1g / 490499168 / A120219 / / 324028-95-7 / MFCD09834827 / 171.580 / C7H6ClNO2
Ambeed / 6-Chloro-4-methylpyridine-2-carboxylic acid / 1g / 490499168 / A120219 / / 324028-95-7 / MFCD09834827 / 171.580 / C7H6ClNO2
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules Ambeed / (2R3R4R5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(24-dioxo-34-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite / 1g / 552739332 / A513418 / / 110764-79-9 / MFCD00792626 / 760.825 / C40H49N4O9P
Ambeed / (2R3R4R5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(24-dioxo-34-dihydropyrimidin-1(2H)-yl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite / 1g / 552739332 / A513418 / / 110764-79-9 / MFCD00792626 / 760.825 / C40H49N4O9P
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules Synthonix / (2S4R)-4-(3-Phenylpropyl)pyrrolidine-2-carboxylic acid hydrochloride / 500mg / 784551887 / AC77553 / / 1049744-68-4 / MFCD06659443 / 269.770 / C14H20ClNO2
Synthonix / (2S4R)-4-(3-Phenylpropyl)pyrrolidine-2-carboxylic acid hydrochloride / 500mg / 784551887 / AC77553 / / 1049744-68-4 / MFCD06659443 / 269.770 / C14H20ClNO2
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eMolecules AstaTech / 2-((BENZYLOXY)IMINO)ACETIC ACID / 0.25g / 794516596 / C10829 / 95.000 / 77845-97-7 / MFCD12910512 / 179.175 / C9H9NO3
AstaTech / 2-((BENZYLOXY)IMINO)ACETIC ACID / 0.25g / 794516596 / C10829 / 95.000 / 77845-97-7 / MFCD12910512 / 179.175 / C9H9NO3
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eMolecules Ambeed / 2-Hydroxy-2-(4-methoxyphenyl)acetic acid / 1g / 525013032 / A117155 / / 10502-44-0 / MFCD00004233 / 182.175 / C9H10O4
Ambeed / 2-Hydroxy-2-(4-methoxyphenyl)acetic acid / 1g / 525013032 / A117155 / / 10502-44-0 / MFCD00004233 / 182.175 / C9H10O4
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules Pharmablock / 2-methyl-5-nitro-pyridine-4-carboxylic acid / 25mg / 586139409 / PB05107 / 0.000 / 342618-24-0 / MFCD18257557 / 182.135 / C7H6N2O4
Pharmablock / 2-methyl-5-nitro-pyridine-4-carboxylic acid / 25mg / 586139409 / PB05107 / 0.000 / 342618-24-0 / MFCD18257557 / 182.135 / C7H6N2O4
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules Ambeed / tert-Butyl 1H-pyrrole-1-carboxylate / 5g / 552749875 / A657885 / / 5176-27-2 / MFCD00209559 / 167.208 / C9H13NO2
Ambeed / tert-Butyl 1H-pyrrole-1-carboxylate / 5g / 552749875 / A657885 / / 5176-27-2 / MFCD00209559 / 167.208 / C9H13NO2
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eMolecules Ambeed / 6-Chloropyridazine-4-carboxylic acid / 100mg / 521439500 / A377581 / / 1256794-24-7 / MFCD15146792 / 158.540 / C5H3ClN2O2
Ambeed / 6-Chloropyridazine-4-carboxylic acid / 100mg / 521439500 / A377581 / / 1256794-24-7 / MFCD15146792 / 158.540 / C5H3ClN2O2
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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